HIPEC surgery, also known as heated or hyperthermic intraperitoneal chemotherapy, is the process of heating chemotherapy drugs and delivering them into the abdominal cavity. This treatment is often combined with cytoreductive surgery and is an effective approach for peritoneal mesothelioma.
During the HIPEC procedure, the surgeon will continuously circulate a heated sterile solution–containing a chemotherapeutic agent–throughout the peritoneal cavity, for a maximum of two hours. The HIPEC procedure is designed to attempt to kill any remaining cancer cells.
The procedure also improves drug absorption and effect with minimal exposure to the rest of the body. In this way, the normal side effects of chemotherapy can be avoided.
There are certain types of cancers which are difficult to treat. Cancers such as Colon Cancers, ovarian cancers which spread to the peritoneum only and not elsewhere are difficult to treat as the chemotherapy finds itself difficult to reach the peritoneum surface and hence these tumors are best treated by HIPEC.
HIPEC stands for Hyperthermic IntraPEritoneal Chemotherapy. Certain cancers which are limited to peritoneum lining can receive HIPEC. In basic language it’s a
chemotherapy medicine which is heated around 42-degreeCelsius so that it penetrates tissues better. Conventional injectable chemotherapy is not able to reach the peritoneal surface and HIPEC delivers chemotherapy straightly to the cancer cells in the abdomen.
Certain cancers such as colon cancers , ovarian cancers , gastric cancers , mesotheliaoms , primary peritoneal carcinomatosis , and appendiceal cancers can be treated by HIPEC surgery.
Can HIPEC be done in all patients who suffer from above mentioned cancers.
NO. HIPEC is a very selective procedure which can only be done in those patients of above mentioned cancers in whome the tumour has not spread beyond the peritoneum. For eg,if the disease has gone to liver or lungs or other parts of the body then HIPEC is contraindicated .
NO. Despite the complexity of the surgery and the hemodynamic changes that happen during the surgery now days HIPEC is a safe surgery with life risk not ranging beyond 3 % in experience hands .
NO. It’s important to realize that HIPEC is a specialized procedure and it can be performed best by those who have good experience in handling this surgery . A good anesthesia unit is equally important as the surgeon who is performing the surgery.
Now a days we are seeing more and more patients surviving the 5yr survival barrier with good Cytoreductive surgery and HIPEC surgery as compared to years back when we used to call these patients incurable.
Refer to our patient testimonial below who is now a 5 year cancer survivor who had Stage IIIC ovarian cancer. A few years back we use to consider these patients inoperable and incurable however now we can aim for cure in these subsets of patient .
Phase I: Cytoreductive Surgery
Firstly, the doctor performs cytoreductive surgery to evacuate as much tumor as possible from the abdominal cavity. Without this surgery, HIPEC is ineffective because the chemo drugs are not able to penetrate deep into cancerous tumors.
Phase I: Cytoreductive Surgery
In this phase, if there are any remaining cancer cells that are left after heated chemotherapy then immediately Chemotherapy Bathsurgery is performed to extend survival and prevent cancer recurrence. Commonly chemotherapy drugs, which are used,are gemcitabine, carboplatin, doxorubicin, pemetrexed, and cisplatin. Rather than injecting these drugs directly your blood, doctors deliver them straightly to patient’sabdomen or chest.